IED ID | IndEnz0018001298 |
Enzyme Type ID | peroxidase001298 |
Protein Name |
Ferric uptake regulation protein Ferric uptake regulator |
Gene Name | fur PA4764 |
Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Enzyme Sequence | MVENSELRKAGLKVTLPRVKILQMLDSAEQRHMSAEDVYKALMEAGEDVGLATVYRVLTQFEAAGLVVRHNFDGGHAVFELADSGHHDHMVCVDTGEVIEFMDAEIEKRQKEIVRERGFELVDHNLVLYVRKKK |
Enzyme Length | 134 |
Uniprot Accession Number | Q03456 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Beta strand (6); Chain (1); Helix (5); Metal binding (8); Region (2); Turn (3) |
Keywords | 3D-structure;Cytoplasm;DNA-binding;Iron;Metal-binding;Reference proteome;Repressor;Transcription;Transcription regulation;Zinc |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | X-ray crystallography (2) |
Cross Reference PDB | 1MZB; 6H1C; |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 15,234 |
Kinetics | |
Metal Binding | METAL 32; /note=Zinc; METAL 80; /note=Zinc; METAL 86; /note=Iron; /evidence=ECO:0000305; METAL 88; /note=Iron; /evidence=ECO:0000305; METAL 89; /note=Zinc; METAL 100; /note=Zinc; METAL 107; /note=Iron; /evidence=ECO:0000305; METAL 124; /note=Iron; /evidence=ECO:0000305 |
Rhea ID | |
Cross Reference Brenda |