| IED ID | IndEnz0018001303 |
| Enzyme Type ID | peroxidase001303 |
| Protein Name |
Hemoglobin subunit alpha Alpha-globin Hemoglobin alpha chain |
| Gene Name | HBA1; HBA2 |
| Organism | Pan paniscus (Pygmy chimpanzee) (Bonobo) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Pan (chimpanzees) Pan paniscus (Pygmy chimpanzee) (Bonobo) |
| Enzyme Sequence | MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR |
| Enzyme Length | 142 |
| Uniprot Accession Number | P69906 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in oxygen transport from the lung to the various peripheral tissues. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Initiator methionine (1); Metal binding (2); Modified residue (17) |
| Keywords | Acetylation;Direct protein sequencing;Heme;Iron;Metal-binding;Oxygen transport;Phosphoprotein;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 4; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 8; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 9; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 12; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 17; /note=N6-acetyllysine; alternate; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 17; /note=N6-succinyllysine; alternate; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 25; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 36; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 41; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 50; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P69905; MOD_RES 103; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 109; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 125; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 132; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 135; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 138; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P01942; MOD_RES 139; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01942 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15174051; |
| Motif | |
| Gene Encoded By | |
| Mass | 15,258 |
| Kinetics | |
| Metal Binding | METAL 59; /note=Iron (heme b distal ligand); METAL 88; /note=Iron (heme b proximal ligand) |
| Rhea ID | |
| Cross Reference Brenda |