Detail Information for IndEnz0018001310
IED ID IndEnz0018001310
Enzyme Type ID peroxidase001310
Protein Name Vanadium-dependent bromoperoxidase
V-BPO
EC 1.11.1.18
Vanadium haloperoxidase
Gene Name
Organism Ascophyllum nodosum (Knotted wrack) (Brown seaweed)
Taxonomic Lineage cellular organisms Eukaryota Sar Stramenopiles Ochrophyta PX clade Phaeophyceae Fucales Fucaceae Ascophyllum Ascophyllum nodosum (Knotted wrack) (Brown seaweed)
Enzyme Sequence QTCSTSDDADDPTPPNERDDEAFASRVAAAKRELEGTGTVCQINNGETDLAAKFHKSLPHDDLGQVDADAFAALEDCILNGDLSICEDVPVGNSEGDPVGRLVNPTAAFAIDISGPAFSATTIPPVPTLPSPELAAQLAEVYWMALARDVPFMQYGTDDITVTAAANLAGMEGFPNLDAVSIGSDGTVDPLSQLFRATFVGVETGPFISQLLVNSFTIDSITVEPKQETFAPDVNYMVDFDEWLNIQNGGPPAGPELLDDELRFVRNARDLARVTFTDNINTEAYRGALILLGLDAFNRAGVNGPFIDIDRQAGFVNFGISHYFRLIGAAELAQRSSWYQKWQVHRFARPEALGGTLHLTIKGELNADFDLSLLENAELLKRVAAINAAQNPNNEVTYLLPQAIQEGSPTHPSYPSGHATQNGAFATVLKALIGLDRGGDCYPDPVYPDDDGLKLIDFRGSCLTFEGEINKLAVNVAFGRQMLGIHYRFDGIQGLLLGETITVRTLHQELMTFAEESTFEFRLFTGEVIKLFQDGTFTIDGFKCPGLVYTGVENCVS
Enzyme Length 557
Uniprot Accession Number P81701
Absorption
Active Site ACT_SITE 411; ACT_SITE 418
Activity Regulation
Binding Site BINDING 341; /note=Vanadate; /evidence=ECO:0000269|PubMed:10543953; BINDING 349; /note=Vanadate; /evidence=ECO:0000269|PubMed:10543953; BINDING 480; /note=Vanadate; /evidence=ECO:0000269|PubMed:10543953; BINDING 486; /note=Vanadate; /evidence=ECO:0000269|PubMed:10543953
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=RH + Br(-) + H(2)O(2) = RBr + 2 H(2)O.; EC=1.11.1.18; Evidence={ECO:0000305};
DNA Binding
EC Number 1.11.1.18
Enzyme Function FUNCTION: Catalyzes the halogenation of organic substrates in the presence of hydrogen peroxide. {ECO:0000269|PubMed:10543953, ECO:0000269|PubMed:8564812}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Beta strand (13); Binding site (4); Chain (1); Disulfide bond (5); Helix (27); Modified residue (1); Region (2); Sequence conflict (7); Turn (4)
Keywords 3D-structure;Direct protein sequencing;Disulfide bond;Metal-binding;Oxidoreductase;Peroxidase;Pyrrolidone carboxylic acid;Vanadium
Interact With
Induction
Subcellular Location
Modified Residue MOD_RES 1; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:10543953
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 1QI9;
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 60,344
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 1.11.1.18;