IED ID |
IndEnz0018001313 |
Enzyme Type ID |
peroxidase001313 |
Protein Name |
Alpha-synuclein
Non-A beta component of AD amyloid
Non-A4 component of amyloid precursor
NACP
|
Gene Name |
SNCA NACP PARK1 |
Organism |
Homo sapiens (Human) |
Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
Enzyme Sequence |
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA |
Enzyme Length |
140 |
Uniprot Accession Number |
P37840 |
Absorption |
|
Active Site |
|
Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
|
DNA Binding |
|
EC Number |
|
Enzyme Function |
FUNCTION: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Alternative sequence (2); Beta strand (7); Chain (1); Compositional bias (1); Helix (5); Metal binding (2); Modified residue (4); Mutagenesis (15); Natural variant (4); Region (3); Repeat (4); Turn (3) |
Keywords |
3D-structure;Acetylation;Alternative splicing;Alzheimer disease;Amyloid;Cell junction;Cell projection;Copper;Cytoplasm;Direct protein sequencing;Disease variant;Membrane;Metal-binding;Neurodegeneration;Nucleus;Parkinson disease;Parkinsonism;Phosphoprotein;Reference proteome;Repeat;Secreted;Synapse;Ubl conjugation |
Interact With |
Q6PCB6; P00519; P00519-1; P00519-2; Q6ZTN6-2; P63010-2; O00203; P02647; P02649; P05067; Q8N6T3-3; Q9NP61; Q0P5N6; Q8WXK3; P18847; Q9H0Y0; P46379-2; Q07812; Q07817; O15392; Q8WUW1; Q5SZD1; P62158; Q8N5S9-2; P55212; Q7Z7K6; Q9HD42; Q16740; P10909; Q9UNS2; Q8IUI8; P48730-2; P99999; O75398; Q8NDP9; O60479; A0AVK6; O75530-2; O00472; Q8TC29; O00471; Q9UHY8; Q0VDC6; Q6PIV2; P02792; P06241; P06241-3; P62879; P49841; P68431; Q71DI3; Q969S8; Q9HCC6; Q8WVV9-3; P09017; P08107; P42858; P80217-2; Q16352; Q6DN90-2; O14713; Q9UIH9; Q9Y2M5; Q92876; Q9BYQ4; Q96JM7-2; P13473-2; Q9BYZ2; Q9H2C1; Q9UPM6; Q8TBB1; Q8N448; A2RU56; Q5S007; O95777; P07948; Q8TD91-2; P10636-6; P10636-8; Q8N6F8; Q8TDB4; A4FUJ8; Q8N594; Q9Y3D2; P00414; P02795; Q9Y483-4; O00746; O15381-5; Q86WS3; Q96FW1; Q6GQQ9-2; Q6VY07; O96013-2; Q9NR21-5; Q9NV79; Q13113; O75925; Q6ZR37; P17252; Q02156; O60260-5; O75400-2; P62191; P17980; Q9UI14; Q9UJ41-4; P62826; Q13702-2; P57052; Q8N5U6; Q6ZNA4-2; Q9ULX5; Q8WVD3; Q8IYW5; Q96D59; Q8N488; O75446; O00560; O43236; O75920-2; Q2NKQ1-4; Q01959; Q9HCE7-2; Itself; Q9Y6H5; Q9Y6H5-2; Q16143; P23497-2; Q99932-2; Q8NHS9; Q8TCT7-2; Q13501; O75886; Q16623; Q9BR01-2; Q92797-2; Q16650; Q13569; P28347-2; Q15554-4; Q9H0E2; O94811; P19474; P68363; P07437; Q8WVJ9; P62987; Q9BSL1; O15205; Q04323-2; Q96RL1-2; O75604-3; P63027; P40337-2; Q9UBQ0-2; Q9GZS3; O00308; Q04917; O43167-2; Q96NC0; Q8WUU4; Q8N895; Q8N988-2; Q68EA5; Q8NBB4-2; A8K878; P0DTC9; Q61327; Itself; Q04917 |
Induction |
|
Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19762560, ECO:0000269|PubMed:24936070, ECO:0000269|PubMed:25561023, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:31034892}. Membrane {ECO:0000269|PubMed:24936070}. Nucleus {ECO:0000269|PubMed:12859192, ECO:0000269|PubMed:24936070}. Cell junction, synapse {ECO:0000269|PubMed:15282274}. Secreted {ECO:0000269|PubMed:24936070}. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274}. |
Modified Residue |
MOD_RES 1; /note="N-acetylmethionine"; /evidence="ECO:0000269|PubMed:22407793"; MOD_RES 87; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:10617630"; MOD_RES 125; /note="Phosphotyrosine; by FYN"; /evidence="ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833"; MOD_RES 129; /note="Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5"; /evidence="ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070" |
Post Translational Modification |
PTM: Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. {ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:10852916, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:24936070}.; PTM: Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.; PTM: Ubiquitinated. The predominant conjugate is the diubiquitinated form. {ECO:0000250|UniProtKB:P37377}.; PTM: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. {ECO:0000269|PubMed:22407793}. |
Signal Peptide |
|
Structure 3D |
X-ray crystallography (12); Electron microscopy (35); NMR spectroscopy (6) |
Cross Reference PDB |
1XQ8;
2JN5;
2KKW;
2M55;
2N0A;
2X6M;
3Q25;
3Q26;
3Q27;
3Q28;
3Q29;
4BXL;
4R0U;
4R0W;
4RIK;
4RIL;
4ZNN;
5CRW;
6A6B;
6CT7;
6CU7;
6CU8;
6FLT;
6H6B;
6I42;
6L1T;
6L1U;
6L4S;
6LRQ;
6OSJ;
6OSL;
6OSM;
6PEO;
6PES;
6RT0;
6RTB;
6SST;
6SSX;
6UFR;
6XYO;
6XYP;
6XYQ;
7C1D;
7E0F;
7L7H;
7LC9;
7NCA;
7NCG;
7NCH;
7NCI;
7NCJ;
7NCK;
7STX;
|
Mapped Pubmed ID |
10319874;
10391242;
10411933;
10583407;
11078745;
11173882;
11207390;
11227130;
11357958;
11401442;
11425308;
11467836;
11472875;
11487204;
11532993;
11701929;
11724769;
11744621;
11748744;
11751692;
11812148;
11812782;
11814343;
11814405;
11823645;
11852183;
118839;
11889756;
11893734;
11900526;
12025860;
12042811;
12044636;
12059041;
12062445;
12070658;
12115139;
12122208;
12124613;
12138709;
12145295;
12151787;
12217698;
12220378;
12239163;
12351642;
12352614;
12367530;
12377775;
12428717;
12428728;
12493604;
12534279;
12534296;
12541013;
12551928;
12576551;
12586824;
12598733;
12672549;
12684441;
1270801;
12714745;
12716427;
12716914;
12727333;
12752402;
12783249;
12784265;
12807436;
12807439;
12815044;
12815663;
12819014;
12857790;
12867415;
12868067;
12868068;
12900507;
12923179;
12923682;
12928483;
12973692;
14506232;
14507911;
14572463;
14583385;
14593171;
14596606;
14627698;
14645218;
14657499;
14657500;
14690528;
14692700;
14699135;
14711827;
14742448;
14996933;
14997013;
15028717;
15050722;
15078109;
15096050;
15103328;
15109581;
15132984;
15135042;
15155902;
15159488;
15180968;
15234109;
15236975;
15247485;
15265037;
15289452;
15300629;
15317865;
15333840;
15338643;
15364911;
15365127;
15455394;
15459341;
15465356;
15496679;
15502874;
15522241;
15541000;
15542733;
15544803;
15576511;
15590652;
15590933;
15591046;
15596612;
15615715;
15622440;
15628875;
15628878;
15641770;
15670652;
15671022;
15671169;
15671870;
15672325;
15684072;
15685368;
15717024;
15718234;
15731118;
15732111;
15755676;
15765523;
15767574;
15791003;
15817478;
15840579;
15845543;
15863497;
15895422;
15896322;
15917102;
15935068;
15935070;
15939304;
15941712;
15944382;
15955578;
15962837;
15976091;
15978696;
15981014;
16020543;
16020550;
16037493;
16051265;
16081040;
16092093;
16110277;
16166095;
16176937;
16216085;
16227205;
16239214;
16242637;
16250025;
16291942;
16297908;
16330147;
16330551;
16338184;
16358335;
16399671;
16403519;
16406146;
16410343;
16455667;
16464864;
16500997;
16516382;
16520971;
16524375;
16543523;
16567160;
16595633;
16604306;
16606366;
16606927;
16611810;
16651889;
16678164;
16679556;
16679557;
16687662;
16752390;
16762368;
16764865;
16780837;
16794039;
16806952;
16824047;
16847063;
16882008;
16896109;
16896314;
16930553;
16934409;
16947080;
16953580;
16957079;
16959772;
16959793;
16981712;
16997873;
17005870;
17010992;
17012252;
17012257;
17017516;
17017543;
17027006;
17049244;
17055279;
17077307;
17078049;
17146290;
17156375;
17156376;
17166628;
17174013;
17176082;
17199224;
17200685;
17209557;
17209570;
17222106;
17254569;
17291816;
17292657;
17309880;
17325715;
17335904;
17373725;
17374032;
17374033;
17374364;
17376994;
17387688;
17408955;
17451452;
17465029;
17489854;
17530780;
17531291;
17531952;
17554782;
17573347;
17576801;
17603039;
17625105;
17653558;
17675576;
17681534;
17683088;
17692832;
17706644;
17708336;
17712623;
17714183;
17785456;
17853477;
17868672;
17872362;
17873367;
17904099;
17918232;
17955272;
17982729;
17985233;
18000672;
18005258;
18018485;
18018486;
18031063;
18036154;
18039462;
18061619;
18065497;
18070888;
18162487;
18162536;
18178617;
18179253;
18182484;
18182779;
18195004;
18195271;
18210157;
18211709;
18245082;
18261456;
18261982;
18282005;
18291704;
18295208;
18314273;
18322262;
18322396;
18322646;
18329380;
18335262;
18343814;
18362284;
18369446;
1837051;
18390556;
18393229;
18404644;
18413475;
18417705;
18423664;
18436529;
18436957;
18449172;
18449945;
18451726;
18463503;
18463504;
18484335;
18485051;
18491043;
1849145;
18492487;
18494470;
18505736;
18539297;
18541113;
18562315;
18566453;
18568448;
18571778;
18606870;
18614564;
18617532;
18622040;
18625222;
18650345;
18676060;
18692132;
18702517;
18702696;
18704197;
18704525;
18708765;
18751989;
18775438;
18824390;
18843496;
18848547;
18852445;
18852892;
18951507;
18955133;
18973254;
18975920;
18985386;
19002552;
19004816;
19018246;
19027885;
19032594;
19047559;
19049426;
19070597;
19071095;
19074459;
19101068;
19115126;
19126542;
19135032;
19139307;
19141614;
19146388;
19151622;
19152986;
19164293;
19183551;
19196539;
19198857;
19203374;
19205068;
19219857;
19220042;
19224617;
19224863;
19248830;
19261853;
19289119;
19291219;
19295143;
19328209;
19345692;
19356597;
19361478;
19369384;
19404653;
19405094;
19410557;
19412953;
19444607;
19460374;
19470380;
19475667;
19476547;
19493164;
19498036;
19501571;
19507712;
19526103;
19526281;
19535993;
19540308;
19548659;
19562770;
19576176;
19576220;
19580781;
19596443;
19609719;
19630439;
19632874;
19646423;
19651612;
19651786;
19655784;
19745811;
19747490;
19759002;
19771175;
19816809;
19826908;
19833127;
19833540;
19834617;
19837084;
19845160;
19847913;
19855133;
19875982;
19878656;
19889641;
19890971;
19891973;
19892735;
19895818;
19915575;
19915576;
20026050;
20029978;
20036828;
20041693;
20043104;
20070850;
20071342;
20074453;
20074637;
20077428;
20089532;
20106983;
20114052;
20121219;
20132485;
20140223;
20148295;
20152114;
20169066;
20334438;
20334701;
20340160;
20356833;
20371330;
20379614;
20381070;
20383623;
20392839;
20403393;
20409326;
20417604;
20423081;
20423294;
20437598;
20445049;
20445061;
20448034;
20463956;
20478361;
20489724;
20506312;
20513365;
20524659;
20524960;
20533263;
20540950;
20540987;
20550572;
20554859;
20599975;
20604806;
20615443;
20620148;
20629174;
20634198;
20640532;
20648655;
20664293;
20668263;
20669025;
20685363;
20693280;
20696318;
20697047;
20697102;
20725866;
20805224;
20807650;
20828147;
20842103;
20847452;
20849899;
20854101;
20855506;
20876215;
20876472;
20887775;
20887871;
20919750;
20945981;
20947801;
20959456;
20969957;
20977677;
21044603;
21044948;
21046180;
21054681;
21058943;
21060011;
21085664;
21103359;
21103907;
21108951;
21116546;
21117662;
21124796;
21127069;
21159074;
21162130;
21166675;
21167933;
21179192;
2118650;
21212878;
21215793;
21235576;
21236518;
21238487;
21245015;
21245577;
21248740;
21255620;
21271299;
21272100;
21280130;
21289072;
21296890;
21300904;
21304957;
21309955;
21310263;
21317042;
21330368;
21330369;
21331461;
21338582;
21342025;
21358815;
21391235;
21412942;
21425343;
21439320;
21443877;
21453448;
21461961;
21466165;
21474915;
21488084;
21489994;
21491910;
21524999;
21527634;
21541339;
21565333;
21570984;
21593311;
21600984;
21601954;
21611169;
21613474;
21641618;
21652707;
21653695;
21656370;
21658409;
21658411;
21672073;
21683963;
21684335;
21689664;
21693148;
21699177;
21700325;
21712045;
21714002;
21718702;
21720016;
21721555;
21736378;
21742527;
21746851;
21756873;
21757905;
21767644;
21779395;
21795682;
21798243;
21798244;
21813214;
21816655;
21819966;
21832049;
21838671;
21846727;
21848810;
21853288;
21858077;
21863007;
21865317;
21880335;
21883224;
21900206;
21905118;
21936000;
21945393;
21953452;
21953697;
21953863;
2195544;
21985244;
21990355;
21993592;
22001247;
22003392;
22009045;
22009151;
22025277;
22029383;
22039514;
22042430;
22045699;
22065755;
22067166;
22076805;
22079575;
22082318;
22090514;
22104010;
22119730;
22131221;
22147697;
22153624;
22155643;
22163275;
22165993;
22166424;
22167382;
22182688;
22207004;
22227187;
22243833;
22248692;
22262231;
22267729;
22275250;
22286107;
22291217;
22302797;
22314685;
22315227;
22315428;
22319455;
22326202;
22334684;
22339654;
22349157;
22350713;
22357653;
22357655;
22367999;
22392151;
22399752;
22399753;
22425546;
22426402;
22436655;
22445250;
22453917;
22475625;
22503729;
22508282;
22508489;
22513881;
22533435;
22537068;
22549133;
22550057;
22552968;
22558453;
22560502;
22573613;
22581044;
22591216;
22610785;
22615757;
22617348;
22619171;
22622968;
22647715;
22669510;
22694188;
22695112;
22701661;
22705949;
22735540;
22737239;
22764233;
22767608;
22771474;
22771809;
22814000;
22821666;
22836259;
22843682;
22850485;
22860160;
22880029;
22892036;
22912757;
22914317;
22923346;
22923347;
22923367;
22936307;
22940885;
22941029;
22944910;
22948283;
22961477;
22974310;
22981881;
22983916;
22986484;
22988096;
23011138;
23013868;
23022913;
23028833;
23038403;
23039195;
23077033;
23077527;
23098910;
23100443;
23123341;
23129765;
23149132;
23153578;
23175842;
23180276;
23182315;
23183827;
23200460;
23201181;
23225002;
23225009;
23244416;
23250862;
23252394;
23283657;
23284971;
23300640;
23300799;
23308173;
23313024;
23314528;
23319586;
23328951;
23333298;
23334595;
23344955;
23349712;
23360753;
23361255;
23362176;
23365056;
23374072;
23374074;
23383169;
23384371;
23392688;
23413261;
23426727;
23437071;
23452040;
23454347;
23454680;
23457458;
23458258;
23463005;
23466394;
23492776;
23499431;
23505409;
23507417;
23509976;
23509978;
23526723;
23532841;
23534813;
23553480;
23562552;
23562579;
23576548;
23580063;
23583776;
23587141;
23603399;
23603979;
23607785;
23609437;
23626796;
23630590;
23656991;
23661100;
23667637;
23669636;
23674386;
23674458;
23674490;
23677647;
23681749;
23703938;
23705016;
23708094;
23737253;
23744071;
23744550;
23796501;
23817832;
23820587;
23823878;
23827677;
23831067;
23853107;
23867236;
23886935;
23891486;
23898972;
23900411;
23916651;
23925565;
23927048;
23934919;
23934970;
23936403;
23938351;
23973294;
23985836;
24010662;
24026176;
24047453;
24058406;
24058647;
24066883;
24066973;
24070323;
2409350;
24099487;
24108358;
24112408;
24113654;
24121116;
24138030;
24148766;
24158851;
24184956;
24191706;
24196876;
24204929;
24218576;
24243558;
24252149;
24256246;
24282614;
24313877;
24326201;
24334770;
24338013;
24352892;
24374342;
24376740;
24381286;
24386307;
24392009;
24392030;
24398085;
24412932;
24415155;
24418406;
24430504;
24434619;
24450731;
24452053;
24460028;
24474688;
24477431;
24486885;
24488133;
24501346;
24527756;
24559643;
24567327;
24578302;
24586710;
24590631;
24599158;
24603074;
24607710;
24623599;
24626988;
24629672;
24656894;
24658140;
24662516;
24671416;
24698767;
24712265;
24723692;
24728187;
24729344;
24742361;
24742669;
24746362;
24752924;
24777780;
24810045;
24823723;
24831002;
24833599;
24860424;
24863655;
24865427;
24867919;
24874737;
24878508;
24879013;
24895406;
24898419;
24905915;
24911099;
24942732;
24973356;
24983211;
24984882;
24999658;
25002524;
25016198;
25024216;
25058424;
25075858;
25090921;
25092551;
25092884;
25109238;
25129240;
25143382;
25156829;
25178429;
25203358;
25210774;
25216651;
25218565;
25231978;
25241761;
25246573;
25255476;
25264250;
25268550;
25296841;
25296989;
25305083;
25319443;
25320964;
25333933;
25345880;
25367384;
25369246;
25383638;
25389903;
25390032;
25393002;
25394490;
25416158;
25427997;
25429104;
25446004;
25448986;
25450466;
25452431;
25452767;
25474758;
25480524;
25484190;
25490121;
25505181;
25524885;
25541488;
25545759;
25554495;
25567480;
25588354;
25589666;
25609381;
25617759;
25635052;
25637461;
25656566;
25657004;
25659148;
25663225;
25665531;
25679387;
25701590;
25713058;
25732184;
25747681;
25756329;
25757154;
25761116;
25790376;
25799501;
25813876;
25817515;
25818009;
25830974;
25833099;
25844871;
25849645;
25851527;
25853980;
25861987;
25865825;
25866763;
25893830;
25896035;
25896939;
25921825;
25931201;
25960998;
25962981;
25967550;
25969543;
25971633;
25990096;
25998655;
26003734;
26017579;
26033182;
26041249;
26055708;
26061766;
26068055;
26079410;
26083886;
26099628;
26114655;
26119103;
26153422;
26159606;
26161848;
26173746;
26181201;
26203864;
26208350;
26214314;
26220523;
26220939;
26265394;
26272943;
26287258;
26297298;
26306801;
26314196;
26323479;
26324905;
26331967;
26346361;
26350119;
26350503;
26363495;
26374630;
26378614;
26381411;
26422361;
26434717;
26453202;
26465922;
26468903;
26475692;
26496610;
26496712;
26523794;
26549058;
26563477;
26582456;
26588454;
26610207;
26639969;
26643113;
26643452;
26666838;
26703192;
26711807;
26719332;
26719384;
26732583;
26756579;
26776090;
26782965;
26807843;
26808899;
26822891;
26839082;
26845568;
26846854;
26852372;
26865505;
26880248;
26965692;
26972727;
27003784;
27004367;
27011009;
27015771;
27019408;
27028329;
27030050;
27048753;
27059609;
27080380;
27091628;
27096366;
27098685;
27101974;
27109470;
27109489;
27112900;
27122549;
27173227;
27177831;
27184464;
27207108;
27211987;
27226637;
27228655;
27248657;
27250986;
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27273030;
27282395;
27298346;
27322472;
27332068;
27335051;
27341336;
27348587;
27352802;
27378017;
27378698;
27382062;
27385586;
27385742;
27393118;
27423554;
27444016;
27457957;
27466509;
27469540;
27478013;
27482083;
27503460;
27517125;
27519280;
27520375;
27522545;
27529376;
27534573;
27535567;
27538639;
27567856;
27573854;
27585855;
27587396;
27628239;
27637804;
27671864;
27685250;
27708076;
27717584;
27745782;
27777137;
27779468;
27803984;
27838048;
27853185;
27863657;
27871937;
27886249;
27901068;
27901101;
27912781;
27938414;
279930;
28004278;
28012952;
28024449;
28028237;
28040347;
28052246;
28053029;
28096359;
28108469;
28112214;
28133550;
28154193;
28167231;
28171705;
28173842;
28180961;
28187176;
28193887;
28195695;
28202670;
28214355;
28223512;
28230968;
28232489;
28257421;
28259622;
28275115;
28288993;
28298083;
28300069;
28300150;
28319736;
28324889;
28327969;
28337542;
28337642;
28351932;
28373279;
28374838;
28386933;
28409245;
28431219;
28434341;
28452474;
28468843;
28482862;
28490713;
28495859;
28534083;
28550528;
28580639;
28599681;
28611062;
28614652;
28619113;
28624352;
28636593;
28647363;
28648742;
28650673;
28651250;
28654636;
28662185;
28671665;
28679767;
28679768;
28698377;
28698628;
28711405;
28711409;
28724388;
28739711;
28739716;
28741930;
28743955;
28759722;
28760825;
28780169;
28801354;
28826027;
28827786;
28841377;
28844730;
28851219;
28855681;
28860381;
28877262;
28914525;
28920936;
28923922;
28933786;
28955066;
28967040;
28970129;
28972595;
28973645;
28984690;
28990084;
28993630;
2900981;
29048372;
29054856;
29100107;
29100980;
29149290;
29171986;
29177427;
29184069;
29189256;
29198173;
29209768;
29233723;
29246724;
29248340;
29252078;
29273335;
29286644;
29298416;
29298733;
29311330;
29313531;
29333980;
29336717;
29369502;
29382725;
29398121;
29407413;
29408361;
29414102;
29422109;
29429047;
29438043;
29459792;
29466944;
29473656;
29483518;
29505953;
29555518;
29571767;
29579237;
29589283;
29603451;
29604263;
29632069;
29633780;
29663556;
29669468;
29669601;
29678776;
29681024;
29704492;
29705185;
29712958;
29725300;
29729894;
29730780;
29743672;
29801501;
29849887;
29851342;
29906099;
29923074;
29941606;
29959729;
29960040;
29967316;
29969391;
29974096;
29976670;
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29991596;
29996045;
29996119;
30065316;
30081046;
30096435;
30120834;
30122122;
30136097;
30137426;
30142705;
30146452;
30146727;
30168437;
30184304;
30194957;
30201422;
30219847;
30239196;
30250046;
30262800;
30266652;
30269383;
30278239;
30290273;
30304516;
30316070;
30327435;
30329047;
30336481;
3035556;
30380895;
30381260;
30385782;
30423204;
30424941;
30465671;
30478174;
30481588;
30485814;
30517862;
30528390;
3053705;
30562735;
30598082;
30615125;
30620180;
30639210;
30639428;
30646912;
30658140;
30689867;
30753527;
30755483;
30755581;
30790619;
30801759;
30805666;
3080684;
30826968;
30862700;
30871620;
30877431;
30901378;
30927235;
3094007;
30943367;
31027150;
31036561;
31041581;
31068782;
31077373;
31095042;
31096048;
31099098;
31102707;
31110017;
31165943;
31182727;
31194700;
31196176;
31211923;
31226488;
31233777;
31234232;
31234238;
31235589;
31257247;
31257259;
31267130;
31267577;
31269263;
31270237;
31275310;
31295458;
31351411;
31358782;
31361367;
31382050;
31391096;
31402119;
3142462;
31424675;
31476446;
31492714;
31507364;
31514384;
31518613;
31524014;
31552762;
31555088;
31600778;
31616427;
31633065;
31635805;
31659041;
31665365;
31674884;
31685606;
31686426;
31695184;
31696585;
31699669;
31701024;
31719530;
31719623;
31721560;
31722116;
31727879;
31733322;
31742923;
31754127;
31755958;
31758049;
31785806;
31792460;
31804560;
31815671;
31830361;
31863812;
31873106;
31912833;
31915018;
31933723;
31954327;
31969389;
31973911;
31976583;
32001504;
32015135;
32015326;
32017806;
32025029;
32035284;
32036337;
32036340;
32039503;
32043464;
32064896;
32069013;
32075919;
32078298;
32096037;
32096038;
32138193;
32143619;
32150777;
32156613;
32157247;
32159944;
32160287;
32164323;
32170541;
32176655;
32192190;
32203130;
32203581;
32220025;
32227952;
32228205;
32234683;
32241921;
32273890;
32291284;
32317654;
32324926;
32327648;
32343709;
32350025;
32356200;
32385113;
32391629;
32394304;
32424039;
32424162;
32426502;
32430178;
32432761;
32444780;
32453651;
32457125;
32457390;
32461689;
32484913;
32493990;
32497661;
32499486;
32503167;
32513706;
32561678;
32568772;
32570982;
32571190;
32595456;
32596926;
32624505;
32652860;
32660565;
32665263;
32669353;
32673459;
32677286;
32686562;
32708732;
32709107;
32719116;
32736645;
32737160;
32747521;
32784058;
32794578;
32819564;
32819572;
32868414;
32868457;
32878882;
32879386;
32892498;
32914394;
32915398;
32921251;
32942768;
32954426;
32971383;
32996158;
33003328;
33003464;
33035800;
33048264;
33066427;
33079553;
33082300;
33122072;
33138150;
33161049;
33177717;
33186583;
33188038;
33211011;
33212758;
33212934;
33228804;
33231251;
33264426;
33268351;
33301617;
33309700;
33332736;
33340152;
33347975;
33357908;
33361597;
33373501;
33373595;
33417300;
33428332;
33446243;
33452693;
33453994;
33477465;
33500442;
33506583;
33539920;
33548114;
33554920;
33556113;
33568632;
33582741;
33587036;
33594256;
33606207;
33608984;
33617693;
33631264;
33649211;
33649398;
33657088;
33664298;
33672321;
33685516;
33705925;
33718373;
33721881;
33743820;
33753734;
33761362;
33769791;
33771571;
33784451;
33798940;
33799982;
33805843;
33854052;
33865938;
33895878;
33903234;
33924585;
33924963;
33933456;
33940158;
33941284;
33972418;
33991233;
34032594;
34036433;
34064816;
34067663;
34072869;
34083630;
34113478;
34139284;
34148543;
34161822;
34175689;
34199427;
34211457;
34233191;
34268903;
34285331;
34288055;
34292621;
34309760;
34312362;
34333522;
34360737;
34371014;
34382268;
34383993;
34390836;
34404758;
34414447;
34431665;
34432157;
34452994;
34502063;
34508096;
34510532;
34526987;
34528272;
34528385;
34530929;
34535638;
34547253;
34555357;
34556785;
34572052;
34577877;
34582997;
34595918;
34613701;
34617653;
34636961;
34662812;
34665617;
34680054;
34680099;
34680141;
34685771;
34716315;
34716339;
34726359;
34730940;
34742290;
34742348;
34754035;
34772466;
34779565;
34780474;
34788284;
34793693;
34819159;
34830348;
34830391;
34831053;
34848256;
34864689;
34884422;
34944443;
34948050;
34948195;
35011649;
35095850;
35137671;
35138035;
35163013;
35163450;
35163733;
35167083;
35169022;
35210396;
35328814;
35346107;
8097946;
8159701;
8464497;
8490014;
8870004;
9006323;
9054935;
9743579;
9862427;
|
Motif |
|
Gene Encoded By |
|
Mass |
14,460 |
Kinetics |
|
Metal Binding |
METAL 2; /note=Copper; /evidence=ECO:0000305; METAL 50; /note=Copper; /evidence=ECO:0000305 |
Rhea ID |
|
Cross Reference Brenda |
|