Detail Information for IndEnz0018001346
IED ID IndEnz0018001346
Enzyme Type ID peroxidase001346
Protein Name 1-Cys peroxiredoxin
EC 1.11.1.24
Thiol-specific antioxidant
Thioredoxin peroxidase
Thioredoxin-dependent peroxiredoxin
Gene Name DDB_G0282517
Organism Dictyostelium discoideum (Slime mold)
Taxonomic Lineage cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold)
Enzyme Sequence MSRIQQVNKSILIRSFCTGAPSKSNFSPVGNFLRIGDVVPDFSQDSSVGQINLYKTLGDSWGLFVSHPKDFTPICTTELGRLAKLKPEFEKRNCKILALSVDSVKDHLEWMKDIEETQKVKINYPIIADQDRKVADLYGMIHPNADNTFTVRSVFFISPDKRLRAQITLPASTGRNFNEIIRILDSFQLTDKYKVATPADWVDGDDCIIVPTVFDEDAKKLFPKGFPKIKSYLRVTPQPNK
Enzyme Length 241
Uniprot Accession Number Q54SE2
Absorption
Active Site ACT_SITE 75; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000250|UniProtKB:P34227
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000250|UniProtKB:P34227};
DNA Binding
EC Number 1.11.1.24
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. {ECO:0000250|UniProtKB:P34227}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (1)
Keywords Antioxidant;Oxidoreductase;Peroxidase;Redox-active center;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 18559084; 22120990;
Motif
Gene Encoded By
Mass 27,301
Kinetics
Metal Binding
Rhea ID RHEA:62620
Cross Reference Brenda