Detail Information for IndEnz0018001356
IED ID IndEnz0018001356
Enzyme Type ID peroxidase001356
Protein Name 1-Cys peroxiredoxin PER1
EC 1.11.1.24
Rehydrin homolog
Thioredoxin peroxidase
Thioredoxin-dependent peroxiredoxin
Gene Name PER1
Organism Triticum aestivum (Wheat)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Pooideae Triticodae Triticeae Triticinae Triticum Triticum aestivum (Wheat)
Enzyme Sequence MPGLTIGDTVPNLELDSTHGKIRIHDYVGNGYVILFSHPGDFTPVCTTELAAMANYAKEFEKRGVKLLGISCDDVQSHKEWTKDIEAYKPGSKVTYPIMADPDRSAIKQLNMVDPDEKDAEGQLPSRTLHIVGPDKKVKLSFLYPSCTGRNMDEVVRAVDSLLTAAKHKVATPANWNPGECVVIAPGVSDDEAKKMFPQGFETADLPSKKGYLRFTKV
Enzyme Length 218
Uniprot Accession Number Q6W8Q2
Absorption
Active Site ACT_SITE 46; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000250|UniProtKB:P30041
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000250|UniProtKB:P30041};
DNA Binding
EC Number 1.11.1.24
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity). {ECO:0000250|UniProtKB:O04005, ECO:0000250|UniProtKB:P30041}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (1); Motif (1)
Keywords Antioxidant;Cytoplasm;Nucleus;Oxidoreductase;Peroxidase;Redox-active center;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O04005}. Cytoplasm {ECO:0000250|UniProtKB:O04005}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 194..217; /note=Bipartite nuclear localization signal; /evidence=ECO:0000255
Gene Encoded By
Mass 23,965
Kinetics
Metal Binding
Rhea ID RHEA:62620
Cross Reference Brenda