Detail Information for IndEnz0018001379
IED ID IndEnz0018001379
Enzyme Type ID peroxidase001379
Protein Name Glutathione S-transferase theta-1
EC 2.5.1.18
GST 5-5
GST class-theta-1
Glutathione S-transferase 5
Gene Name Gstt1
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MVLELYLDLLSQPCRAIYIFAKKNNIPFQMHTVELRKGEHLSDAFAQVNPMKKVPAMKDGGFTLCESVAILLYLAHKYKVPDHWYPQDLQARARVDEYLAWQHTTLRRSCLRTLWHKVMFPVFLGEQIRPEMLAATLADLDVNVQVLEDQFLQDKDFLVGPHISLADVVAITELMHPVGGGCPVFEGRPRLAAWYRRVEAAVGKDLFLEAHEVILKVRDCPPADPVIKQKLMPRVLTMIQ
Enzyme Length 240
Uniprot Accession Number Q01579
Absorption
Active Site
Activity Regulation
Binding Site BINDING 40; /note=Glutathione; /evidence=ECO:0000250
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:20097269};
DNA Binding
EC Number 2.5.1.18
Enzyme Function FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. {ECO:0000269|PubMed:20097269}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (1); Chain (1); Domain (2); Initiator methionine (1); Region (2)
Keywords Cytoplasm;Direct protein sequencing;Reference proteome;Transferase
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11453994; 12588193; 23111281; 30444463; 31063713; 9331086; 9344408; 9729437; 9794803; 9855024;
Motif
Gene Encoded By
Mass 27,468
Kinetics
Metal Binding
Rhea ID RHEA:16437
Cross Reference Brenda