| IED ID | IndEnz0018001404 |
| Enzyme Type ID | peroxidase001404 |
| Protein Name |
Vanadium-dependent bromoperoxidase EC 1.11.1.18 Vanadium haloperoxidase |
| Gene Name | |
| Organism | Corallina officinalis (Coral seaweed) |
| Taxonomic Lineage | cellular organisms Eukaryota Rhodophyta Florideophyceae Corallinophycidae Corallinales Corallinaceae Corallinoideae Corallina Corallina officinalis (Coral seaweed) |
| Enzyme Sequence | MGIPADNLQSRAKASFDTRVSAAELALARGVVPSLANGEELLYRNPDPENGDPSFIVSFTKGLPHDDNGAIIDPDDFLAFVRAINSGDEKEIADLTLGPARDPDTGLPIWRSDLANSLELEVRGWENSSAGLTFDLEGPDAQSIAMPPAPVLTSPELIAEIAELYLMALGREIEFSEFDSPKNAEYIQFAIDQLNGLEWFNTPAMLGDPPAEIRRRRGEVTVGNLFRGILPGSEVGPYLSQYIIVGSKQIGSATGGNKTLVSPNAADEFDGEIAYGSITISQRVRIATPGRDFMTDLKVFLDVQDAADFRGFESYEPGARLIRTIRDLATWVHFDALYEAYLNACLILLANRVPFDPNIPFQQEDKLDNQDVFVNFGDAHVLSLVTEVATRALKAVRYQKFNIHRRLRPEATGGLISVNKIAAEKGESVFPEVDLAVEELEDILEKAEISNRKQNIADGDPDPDPSFLLPQAFAEGSPFHPSYGSGHAVVAGACVTILKAFFDSNFQIDQVFEVDKDEDKLVKSSFKGTLTVAGELNKLADNIAIGRNMAGVHYFSDQFESILLGEQVAIGILEEQSLTYGENFFFNLPKFDGTTIQI |
| Enzyme Length | 598 |
| Uniprot Accession Number | Q8LLW7 |
| Absorption | |
| Active Site | ACT_SITE 480; /evidence=ECO:0000250; ACT_SITE 487; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | BINDING 400; /note=Vanadate; /evidence=ECO:0000250; BINDING 408; /note=Vanadate; /evidence=ECO:0000250; BINDING 547; /note=Vanadate; /evidence=ECO:0000250; BINDING 553; /note=Vanadate; /evidence=ECO:0000250 |
| Calcium Binding | CA_BIND 361..370 |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=RH + Br(-) + H(2)O(2) = RBr + 2 H(2)O.; EC=1.11.1.18; Evidence={ECO:0000269|PubMed:12121762}; |
| DNA Binding | |
| EC Number | 1.11.1.18 |
| Enzyme Function | FUNCTION: Catalyzes the halogenation of organic substrates in the presence of hydrogen peroxide. {ECO:0000269|PubMed:12121762}. |
| Temperature Dependency | |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:12121762}; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (14); Binding site (4); Calcium binding (1); Chain (1); Helix (27); Mutagenesis (1); Region (1); Turn (6) |
| Keywords | 3D-structure;Metal-binding;Oxidoreductase;Peroxidase;Vanadium |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1QHB; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 65,459 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.2 mM for bromide {ECO:0000269|PubMed:12121762}; KM=1.8 mM for iodide {ECO:0000269|PubMed:12121762}; KM=17 uM for H(2)O(2) {ECO:0000269|PubMed:12121762}; |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 1.11.1.18; |