Detail Information for IndEnz0018001413
IED ID IndEnz0018001413
Enzyme Type ID peroxidase001413
Protein Name Thioredoxin-1
DmTrx-1
Protein deadhead
Gene Name dhd Trx-1 CG4193
Organism Drosophila melanogaster (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly)
Enzyme Sequence MASVRTMNDYHKRIEAADDKLIVLDFYATWCGPCKEMESTVKSLARKYSSKAVVLKIDVDKFEELTERYKVRSMPTFVFLRQNRRLASFAGADEHKLTNMMAKLVKA
Enzyme Length 107
Uniprot Accession Number P47938
Absorption
Active Site ACT_SITE 31; /note=Nucleophile; ACT_SITE 34; /note=Nucleophile
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development. {ECO:0000269|PubMed:11877442, ECO:0000269|PubMed:9106167}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Beta strand (4); Chain (1); Disulfide bond (1); Domain (1); Helix (4); Mutagenesis (2); Site (3); Turn (3)
Keywords 3D-structure;Disulfide bond;Electron transport;Nucleus;Redox-active center;Reference proteome;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14579129}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (1)
Cross Reference PDB 6ZMU;
Mapped Pubmed ID 10588726; 11158675; 11796729; 12072466; 12221129; 12408803; 12756181; 14602076; 14605208; 14630943; 15186491; 15644209; 15927177; 16313561; 16412701; 17199047; 17301052; 17567437; 17701050; 17728343; 19348653; 19543366; 20220848; 20371351; 20600005; 21074052; 21205669; 22398207; 22949888; 23071443; 23213441; 24212093; 25246242; 25761110; 25862286; 26257181; 26551273; 26801178; 26896327; 26950602; 27230753; 27486580; 27626494; 27876811; 28031247; 28428068; 29897613; 30082411; 30110626; 30294342; 30810797; 31690598; 31722958; 32134927; 32243476; 33083121; 33306674; 33708404; 34553686; 34982772; 7926776; 8878676; 9247640; 9362474; 9450931;
Motif
Gene Encoded By
Mass 12,384
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda