Detail Information for IndEnz0018001422
IED ID IndEnz0018001422
Enzyme Type ID peroxidase001422
Protein Name Selenoprotein F
15 kDa selenoprotein
Gene Name Selenof Sep15
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MAAGQGGWLRPALGLRLLLATAFQAVSALGAEFASEACRELGFSSNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
Enzyme Length 162
Uniprot Accession Number Q9ERR7
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity). {ECO:0000250|UniProtKB:O60613, ECO:0000250|UniProtKB:Q923V8}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Non-standard residue (1); Sequence conflict (4); Signal peptide (1)
Keywords Endoplasmic reticulum;Reference proteome;Selenocysteine;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..28; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 11898406; 12466851; 12520002; 12600282; 12904583; 14610273; 15883644; 16075368; 16129668; 16236027; 18799693; 19723774; 20388823; 21267068; 21677750; 21768092; 21858002; 23226526; 25886253; 27645994; 29719252; 31958640; 32995962; 34638991; 9535873;
Motif
Gene Encoded By
Mass 17,806
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda