| IED ID | IndEnz0018001447 |
| Enzyme Type ID | peroxidase001447 |
| Protein Name |
Cell pattern formation-associated protein stuA Stunted protein A |
| Gene Name | stuA AN5836 |
| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Nidulantes Emericella nidulans (Aspergillus nidulans) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Enzyme Sequence | MASMNQPQPYMDVHSHLSSGQTYASHPATAGALTHYQYPQQPPVLQPTSTYGPASSYSQYPYPNSVASSQSVPPPTTSISSQVPAQLLPLPVTNHPVPTHGYGNNSGTPMQGYVYDPTGQMAPPGAKPRVTATLWEDEGSLCYQVEAKGVCVARREDNGMINGTKLLNVAGMTRGRRDGILKSEKVRNVVKIGPMHLKGVWIPFDRALEFANKEKITDLLYPLFVQHISNLLYHPANQNQRNMTVPDSRRLEGPQPVVRTPQAQQPPSLHHHSLQTPVPSHMSQPGGRPSLDRAHTFPTPPASASSLIGITSQNNSYDWNPGMNSSVPNTQPLSIDTSLSNARSMPTTPATTPPGNNLQGMQSYQPQSGYDSKPYYSAAPSTHPQYAPQQPLPQQSMAQYGHSMPTSSYRDMAPPSSQRGSVTEIESDVKTERYGQGTVAKTEPEQEQEYAQPDSGYNTGRGSYYTTNPSVGGLAHDHSQLTPDMTGSPQQNGSGRMTPRTSNTAPQWAPGYTTPPRPAAASSLYNIVSDTRGTSGANGSTSDNYSVASNSGYSTGMNGSMGSNKRMRDDDDDRIVPPDSRGEFDTKRRKTLTETPVGGPVGGVPLGLQPMKAGGSLISARR |
| Enzyme Length | 622 |
| Uniprot Accession Number | P36011 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 163..184; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00630 |
| EC Number | |
| Enzyme Function | FUNCTION: Transcription factor that regulates asexual reproduction (PubMed:1516832, PubMed:8722771, PubMed:9312029, PubMed:25550299). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:9312029, PubMed:25359270). Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia (PubMed:1516832). Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene (PubMed:9312029). Controls the expression of the catalase-peroxidase gene cpeA (PubMed:12455692). Plays an important role in cell wall biogenesis during the development by controlling the transcription level of fksA (PubMed:25359270). {ECO:0000269|PubMed:12455692, ECO:0000269|PubMed:1516832, ECO:0000269|PubMed:25359270, ECO:0000269|PubMed:25550299, ECO:0000269|PubMed:8722771, ECO:0000269|PubMed:9312029}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (4); DNA binding (1); Domain (1); Region (5) |
| Keywords | Conidiation;DNA-binding;Nucleus;Reference proteome;Sporulation;Transcription;Transcription regulation |
| Interact With | |
| Induction | INDUCTION: Expression is increased 50-fold during the establishment of developmental competence (PubMed:1516832, PubMed:2062309, PubMed:17630328). Expression is positively controlled by brlA (PubMed:1516832). Expression is also regulated by the LAMMER kinase lkhA (PubMed:23516554). {ECO:0000269|PubMed:1516832, ECO:0000269|PubMed:2062309, ECO:0000269|PubMed:23516554}. |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25550299, ECO:0000269|PubMed:9379904}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 66,956 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |