Detail Information for IndEnz0018001504
IED ID IndEnz0018001504
Enzyme Type ID peroxidase001504
Protein Name Peroxiredoxin-2D
EC 1.11.1.25
Glutaredoxin-dependent peroxiredoxin
Peroxiredoxin IID
Thioredoxin peroxidase 2D
Gene Name PRXIID At1g60740 F8A5.25
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MAPITVGDVVPDGTISFFDENDQLQTVSVHSIAAGKKVILFGVPGAFTPTCSMSHVPGFIGKAEELKSKGIDEIICFSVNDPFVMKAWGKTYQENKHVKFVADGSGEYTHLLGLELDLKDKGLGIRSRRFALLLDNLKVTVANVENGGEFTVSSAEDILKAL
Enzyme Length 162
Uniprot Accession Number O22711
Absorption
Active Site ACT_SITE 51; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000250|UniProtKB:A9PCL4
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62624, Rhea:RHEA-COMP:10729, Rhea:RHEA-COMP:10730, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.25; Evidence={ECO:0000250|UniProtKB:A9PCL4};
DNA Binding
EC Number 1.11.1.25
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (By similarity). May be involved in intracellular redox signaling (Probable). {ECO:0000250|UniProtKB:A9PCL4, ECO:0000305|PubMed:15890615}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Domain (1); Erroneous gene model prediction (1); Sequence conflict (2)
Keywords Antioxidant;Cytoplasm;Oxidoreductase;Peroxidase;Redox-active center;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:12913160}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11997378; 14500793; 14749482; 15032878; 15632145; 16183842; 16606633; 16709196; 16915352; 17644812; 17828791; 18307990; 18493039; 18650403; 18775970;
Motif
Gene Encoded By
Mass 17,472
Kinetics
Metal Binding
Rhea ID RHEA:62624
Cross Reference Brenda