Detail Information for IndEnz0018001572
IED ID IndEnz0018001572
Enzyme Type ID peroxidase001572
Protein Name Thiol peroxidase
Tpx
EC 1.11.1.24
Peroxiredoxin tpx
Prx
Thioredoxin peroxidase
Thioredoxin-dependent peroxiredoxin
Gene Name tpx lin1625
Organism Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Listeriaceae Listeria Listeria innocua Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Enzyme Sequence MTQVTFKHNPVTLVGTERKVGDKAPNFTVVNRDLEEVTLHDYDGKVRLISVVPSIDTSVCSTQTRKFNEEASNLDNTVVLTISVDLPFAQKKWCAAEGLPNAITLSDHRDLSFGEAYGVIMKELRLLARSVFVVNAKGEIVYTEVVPEGSDHPNYEAAIEAAKKA
Enzyme Length 165
Uniprot Accession Number Q92BC5
Absorption
Active Site ACT_SITE 60; /note=Cysteine sulfenic acid (-SOH) intermediate; /evidence=ECO:0000255|HAMAP-Rule:MF_00269
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:50058; EC=1.11.1.24; Evidence={ECO:0000255|HAMAP-Rule:MF_00269};
DNA Binding
EC Number 1.11.1.24
Enzyme Function FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. {ECO:0000255|HAMAP-Rule:MF_00269}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (1); Domain (1)
Keywords Antioxidant;Disulfide bond;Oxidoreductase;Peroxidase;Redox-active center
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,163
Kinetics
Metal Binding
Rhea ID RHEA:62620
Cross Reference Brenda