| IED ID | IndEnz0020000012 |
| Enzyme Type ID | mannase000012 |
| Protein Name |
Beta-mannosidase A EC 3.2.1.25 Mannanase A Mannase A |
| Gene Name | mndA AFUA_6G08840 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MHVKAETVLALLTPAPPSVVGQHVVDLSGDGWTLSSTALNRTVPGHLPSQVHLDLFEAGVIDIMASMILTFVGLRMPIGRIPATRLKAYFESTWLVFDGLDTFATITFCDQHVGSTDNQFRQHHFDVSQILKECKQDPVLRINFGSAPNIANTIAKSPDAEEWPPGVQITNEYPNRWYIRKEQSDFGWDWGPAFAPVGPWKPSYIVQNGHAELYVLNTDIDIYRQGQINYLPPDQSQPWIVNASIDFLGPVPCKPSMSIEIKDAATGSVLSSGLLQNVTVSGKSITGTTTIDGDAPKLWWPSGMGKQNLYNVTITVQNDMKKSLAKVTKRTGFRTIFLNQRNITDDQLAQGIAPGANWHFEINGYEFYTKGSNIIPPDAFWPRVTQARMARLFDAVTAGNQNMLRVWASGAYLHDFIYDLADEKGILLWSEFQFSDALYPVNDAFLENVAAEVVYNVRRVNHHPSLALWAGGNEIESLMLPMARRADPTGYSKYIGEYEKLYISLILPLVYENTRSITYSPSSTTEGYLYVNLSAPVPMAERYSNTTPGSYYGDTDYYNYDTSVSFDYNHYPVGRFANEFGFHSMPSLQTWQQAVDPEDLQFNSSVVVLRNHHYTAGGLFTDNFKNSSKGMGEMTMGVEAYYPIPSKSDSVANFSAWCHATQLFQADLYKSQIQFYRRGSGMPERQLGSLYWQLEDIWQAPTWAGIEYDGRWKVLHYVARDIYQPIIVSPFWNYTTGRLEVYVTSDLWEPAQGTVNLTWVDLSGKSIANNAGTPETVSFTVGALNTTNIYTTNISELSLPDLKDSILILSLSGEGRLPNASSKKAFVHQNHFTPVFPKDLSLKDPKLEVSYSPESRKFTVQATGGVSLYTWLDYPAGAVGYFEANAFVLLPGVPKEVSFVAQEGNVTDDWLQRVTVQSLWDQKVRD |
| Enzyme Length | 926 |
| Uniprot Accession Number | Q4WMS9 |
| Absorption | |
| Active Site | ACT_SITE 474; /note=Proton donor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.; EC=3.2.1.25; |
| DNA Binding | |
| EC Number | 3.2.1.25 |
| Enzyme Function | FUNCTION: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Glycan metabolism; N-glycan degradation. |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (15); Signal peptide (1) |
| Keywords | Carbohydrate metabolism;Glycoprotein;Glycosidase;Hydrolase;Polysaccharide degradation;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 103,736 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |