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Detailed Information for N00008
IPAD-DB ID
N00008
Name
AGuIX@PEG@LPFFD@Cy5.5
Category
Nano-inhibitors
EC
50
IC
50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Aβ1-42
Effects
Bind selectively amyloid plaque constituted by Aβ protein on ex vivo AD mouse hippoacampus; bind and to discriminate Aβ1–42 amyloid fibrils
Research Models
APPswe/PS1A246E/TTR mice; docking study
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