IPAD-DB ID |
N00023 |
Name |
Congo Red/Rutin-MNPs |
Category |
Nano-inhibitors |
EC50 |
- |
IC50 |
- |
Inhibition |
- |
Toxicity |
Treatment of cells with Rutin-MNPs that had no targeted molecular Congo red reduced cytotoxicity |
ROS(reactive oxygen species) |
The treatment of cells with Rutin-MNPs or Congo red-MNPs+Rutin diminished the levels of ROS by 48% and 50%, respectively, compared to cells exposed to Aβ+Cu 2+ |
Metal Chelating |
Cu and Zn |
BBB(blood-brain barrier) |
PASS |
Target Protein |
Aβ1-42 |
Effects |
(1) Congo red-MNPs+Rutin also increased the cell viability to about 90%; (2) Congo red/Rutin-MNPs effectively reduced the generation of NO; |
Research Models |
G SH-SY5Y neuroblastoma cells, APPswe/PS1dE9 transgenic mice, |
Main Source |
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Ref. Link |
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