Detailed Information for N00056
IPAD-DB ID N00056
Name UCNP@DEPE-PEG2000-NH2
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating Cu2+
BBB(blood-brain barrier)
Target Protein Aβ1-42
Effects Be used for the detection of Cu2+ levels and targeting/imaging the Aβ42 in zebrafish and AD mice; capture Cu2+ from Cu2+- Aβ42 conjugate and inhibit Cu2+-induced Aβ42-aggregation and the consequent cell apoptosis
Research Models PC12 cells; C57BL6 and APPsw/PSEN1 mice; zebrafish
Main Source
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