(1) The results of in vitro cell line study revealed that pretreatment of Neuro-2a cell lines with ABS (5 & 10 μg/ml) significantly suppressed the production of free radicals such as reactive oxygen species (ROS) /reactive nitrogen species (RNS) , and also augmented the ROS mediated macromolecular damages and loss of mitochondrial membrane potential induced by toxic Aβ peptide; (2) ABS protects the cells from Aβ induced apoptosis and reduced expression of Bax and induced expression of Bcl-2 proteinsnd;
