Detailed Information for N00063
IPAD-DB ID N00063
Name MF-CCNc
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein IL-1β、IL-6、TNF-α
Effects (1) MF-CCNc decreased the levels of these cytokines significantly in comparison to standard drug Dpz and MF. The p-value of MF-CCNc in comparison to MF and Dpz in IL-1β is (p < 0.0001) (2) A significant decrease in the level of IL-6 of MF-CCNc in comparison to MF was observed with a p-value of (p < 0.05) (3) he level of TNF-α was also reduced significantly in comparison to MF and Dpz with a p-value corresponding to (p < 0.01)
Research Models The scopolamine-induced rat model
Main Source
Ref. Link