Detailed Information for N00065
IPAD-DB ID N00065
Name triphenylphosphonium gold-supported ceria nanoparticles(TPP–AuCeO 2)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein mitochondria
Effects (1) The cellular viability at 10 µg/mL and 20 µg/mL for each NP showed a slight but nonsignificant decrease in cellular viability and proliferation rate after 72 h, being more pronounced at the higher concentration compared to controls (p = 0.085) (2) While treatment with CeO2 and AuCeO2 increased the mitochondrial O2 consumption rate slightly (p = 0.354 and p = 0.196, respectively) , TPP–AuCeO2 induced a significant increase compared to untreated control cells (p < 0.01) (3) A decrease in ∆Ψm in cells treated with CeO2 was observed with respect to untreated control cells (p < 0.05) . However, when Au NPs were supported on CeO2, the AuCeO2 solid exhibited a slight ∆Ψm increase compared to negative controls. This ∆Ψm increase was higher and statistically significant when cells were treated with TPP–AuCeO2 (p < 0.01 compared to control cells and p < 0.001 compared to CeO2-treated cells)
Research Models The human cervical carcinoma cell line, HeLa cells
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