Detailed Information for N00067
IPAD-DB ID N00067
Name nCeO 2
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Acetylcholinesterase (AChE)
Effects (1) NCeO2 at a concentration of 1 mM significantly affected the climbing activity of elav; htau flies(2) nCeO2 also elicited a significant decrease in htau gene expression at both concentrations and increased the mRNA expression of key autophagy genes ATG1 and ATG18
Research Models A pan-neuronal model (elav; htau) of AD, an eye-specific model of htau expression (GMR; htau)
Main Source
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