3.3 nm L- and D-glutathione stabilized gold nanoparticles
Category
Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
Without noticeable toxicity.
ROS(reactive oxygen species)
Metal Chelating
Au
BBB(blood-brain barrier)
PASS
Target Protein
Aβ
Effects
D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairme.
