Detailed Information for N00084
IPAD-DB ID N00084
Name poly (D,L-lactic acid-co-glycolic acid) (PLGA)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity The effects of DBP-PLGA nanoparticles on not only modulating the microglial response, but also reducing neurotoxicity by Aβ.
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ
Effects (1) DBP-PLGA nanoparticles inhibit the polymerization and accumulation ofAβ in both in vitro and in vivo. (2) DBP-PLGA nanoparticles ameliorate Aβ-associated neuroinflammation and neuronal loss of 5XFAD mice. (3) DBP-PLGA nanoparticles significantly ameliorate cognitive impairment of5XFAD mice.
Research Models 5XFAD mice
Main Source
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