Detailed Information for N00091
IPAD-DB ID N00091
Name KLVFF peptide-NPs(NPs)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) NO
Target Protein
Effects (1) Demonstrated the possibility of delivering an active compound across the BBB using g7-NPs injected in a mouse model for AD(2) these K-NPs have equal or increased activity compared to the free peptide, possibly due to increased peptide stability. Thus, these K-NPs possess full therapeutic potential and overcome the limitations for brain-targeted delivery of the free peptide.
Research Models Alzheimer disease (AD)
Main Source
Ref. Link