Detailed Information for N00097
IPAD-DB ID N00097
Name α-mangostin (αM) -loaded poly(ethylene glycol) -poly(l-lactide) (PEG-PLA) nanoparticles (NP-αM)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ
Effects (1) NP-corona complexes with αM loading (0d-NP-αM-corona or 7d-NP-αM-corona) resulted in a significant higher percentage transport compared with that unloaded (0d-NP-corona or 7d-NP-corona) (2) the levels of 395 proteins were enhanced in 0d-NP-αM-corona compared with 0d-NP-corona, while that of 162 proteins were upregulated in 7d-NP-αM-corona compared with 7d-NP-corona,compared with 0d-NP-corona, 465 proteins were upregulated in 7d-NP-corona, while compared with 0d-NP-αM-corona, 578 proteins were upregulated in 7d-NP-αM-corona(3) nanoparticles showed higher brain transport efficiency and microglia uptake efficiency after αM loading and multiple administration
Research Models Immortalized mouse brain endothelial cell line b.End3 and immortalized mouse microglial cell line BV-2
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