Detailed Information for N00105
IPAD-DB ID N00105
Name SWNT-BMP
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Effects (1) Aβ 25–35 (100 μM) was mixed with 10 μg mL–1 SWNTs, 0.5 μg mL–1 BMPs, or 10 μg mL–1 SWNT–BMP hybrid (SWNT : BMP = 20 : 1) , After 3 h, both SWNTs and SWNT–BMP hybrid showed inhibition of Aβ fibrillation, whereas BMPs did not show such behavior(2) Aβ mixed with the SWNT–BMP hybrid treated SH-SY5Y cells showed an approximately 30% increase of cell viability compared with the Aβ injured cells.
Research Models A human-derived cell line, SH-SY5Y (neuroblastoma)
Main Source
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