the peptide D1 containing a spacer of polyethyleneglycol (PEG) (GNR-PEG-D1)
Category
Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
Aβ
Effects
(1) Indicate an increase in fluorescence intensity by a factor of 2.5 (p = 0.0011) and 3 (p < 0.0001) for the samples with 0.1 and 0.5 nM GNR-PEG-D1, respectively(2) The addition of GNR-PEG-D1 produced an increase in the fluorescence of the CRANAD-2 probe bound to the Aβ fibrils(3) A lesser fluorescence enhancement was observed at higher GNR-PEG-D1 concentrations (1 nM) , possibly due to a quenching effect produced by the plasmonic nanoparticles
