Detailed Information for N00108
IPAD-DB ID N00108
Name TPP-ceria NPs
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species) markedly inhibit Aβ-induced mitochondrial ROS
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ
Effects Reduce Aβ-induced neuronal cell loss；mitigate brain inflammation by reducing mitochondrial ROS levels；mitigate the reactive gliosis and suppress neuronal death in mice
Research Models SH-SY5Y，U373，HeLa and HT22 cells；5XFAD and B6/SJL mice
Main Source
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