Detailed Information for N00116
IPAD-DB ID N00116
Name nanostructure, apolipoprotein E3-reconstituted high density lipoprotein (ApoE3-rHDL)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ
Effects (1) That ApoE3-rHDL might serve as a novel nanomedicine for disease modification in AD by accelerating Aβ clearance (2) Justified the concept that nanostructures with Aβ-binding affinity might provide a novel nanoplatform for AD therapy.
Research Models Sprague–Dawley (SD) rat SAMP8 and SAMR1 mice
Main Source
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