| Effects |
(1) Improvement of EGCG stability and effectiveness when loaded in PEGylated PLGA NPs within an antioxidant environment. (2) EGCG/AA NPs were able to increase drug permanence in blood stream and brain tissue, reduce the Aβ plaques burden, Aβ42 peptide levels and neuroinflammation, and enhance synaptogenesis, memory and learning process. (3) All these facts contributed to a significant reduction of cognitive impairment in APP/PS1 mice. (4) EGCG/AA NPs as a novel, safe and suitable therapeutic alternative for the treatment of AD. |
