Detailed Information for N00122
IPAD-DB ID N00122
Name Gold nanorods with peptides D1 and Angiopep 2 (GNRs-D1/Ang2)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ
Effects (1) Nanoconjugate does not affect neuronal viability; it penetrates the cells, and decreases aggregation of Aβ peptide in vitro. (2) when apply nanosystem to a Caenorhabditis elegans AD model, the toxicity of aggregated Aβ peptide is decreased. (3) This work may contribute to the development of therapies for AD based on metallic nanoparticles.
Research Models Nanosystem in a C. elegans model
Main Source
Ref. Link