| Effects |
(1) Hep-SPION could bind Aβ and heparin was essential for the interaction. Furthermore, Hep-SPION promoted the transition of Aβ into the more benign fibrils. This in turn could protect neuronal cells from Aβ induced cytotoxicity. (2) As iron oxide nanoparticles have been widely applied as MRI contrast agents and drug carriers,23, 24, 25 Hep-SPION can potentially be a useful platform for future imaging and drug delivery studies targeting Aβ. |
