Detailed Information for N00127
IPAD-DB ID N00127
Name Reconstituted rHDL-rApoJ nanoparticles(rHDL-rApoJ )
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ
Effects (1) RHDL-rApoJ maintained the ability to prevent the Aβ fibrillization and mediated a higher cholesterol efflux from cultured macrophages (2) rHDL-rApoJ maintained the ability to prevent the Aβ fibrillization and mediated a higher cholesterol efflux from cultured macrophages
Research Models 24-month-old APP23 and wt mice
Main Source
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