| IPAD-DB ID |
N00129 |
| Name |
Multifunctional Carbon Dots |
| Category |
Nano-inhibitors |
| EC50 |
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| IC50 |
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| Inhibition |
|
| Toxicity |
Multifunctional carbon dots that (i) effectively chelate Cu(II) , (ii) suppress Aβ selfassembly and toxicity, and (iii) photodynamically oxidize Aβ residues. |
| ROS(reactive oxygen species) |
An hour of light irradiation further boosted the inhibitory efficacy of OPCDs by leading ROS generation from the photoluminescent OPCDs, which enabled tunable oxygenation on Aβ’s key residues such as His and Met. |
| Metal Chelating |
Cu |
| BBB(blood-brain barrier) |
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| Target Protein |
Aβ |
| Effects |
OPCDs’ multiple effects in chelating Cu(II) , inhibiting Aβ self-assembly, and photooxygenating Aβ residues leads to the highest recovery of cell viability by synergistically degrading toxic aggregates of Aβ-Cu(II) complexes. |
| Research Models |
The PC12 cell derived from rat pheochromocytoma. |
| Main Source |
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| Ref. Link |
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