Detailed Information for N00130
IPAD-DB ID N00130
Name Cationic biopolymer core/shell nanoparticles (Chitosan@PLGA C/SNPs)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ
Effects (1) Cationic Chitosan@LT-PLGA C/SNPs help in transporting LT to brain via intranasal route and the LT is able to supress the oxidative stress inside the cells(2) LT as potential remedy for decreasing oxidative stress while Chitosan@LT-PLGA C/SNPs as efficient carrier and intranasal route as an efficient route for brain targeting of LT in the treatment of AD.
Research Models SH-SY-5Y cell line
Main Source
Ref. Link