Tf-functionalized stealth liposomes loaded with GA for AD therapy
Category
Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
PASS
Target Protein
Aβ1-42
Effects
(1) GA-loaded liposomes were not affected by the functionalization with Tf (p > 0.05) (2) GA-loaded Tf-functionalized liposomes could inhibit Aβ aggregation and fibrillation and disrupt preformed fibrils.
Research Models
The ability of GA-loaded Tf-functionalized liposomes to inhibit Aβ1-42 aggregation was assessed using a ThT fluorescence assay; An in vitro model of AD
