Cu (I) chelator D-penicillamine was covalently conjugated to nanoparticles
Category
Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
Cu
BBB(blood-brain barrier)
PASS
Target Protein
Aβ1-42
Effects
(1) We have shown that d-penicillamine, an approved metal chelator, can be attached to the nanoparticles via either disulfide or thioether conjugation. (2) Moreover, d-penicillamine can be released from the nanoparticles under reducing conditions and released d-penicillamine can solubilize copper–Aβ (1–42) aggregates in vitro
