Detailed Information for N00152
IPAD-DB ID N00152
Name ApoE3 Conjugated Donepezil Nanomedicine
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ1-42
Effects (1) The presence of the ApoE3 significantly modified the morphology of Aβ fibrils and also inhibited the formation Aβ oligomers.(2) ApoE3 donepezil nanoparticles exhibited neuroprotection in the Aβ1-42 induced model by mitigating the pathological features and cognitive impairments
Research Models Wistar rats and Human neuroblastoma cells (SH-SY5Y, NCCS)
Main Source
Ref. Link