Detailed Information for N00159
IPAD-DB ID N00159
Name graphene oxide (GO) loaded with dauricine (Dau)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Aβ1-42
Effects (1) Both in the SH-SY5Y cell model and the Aβ1-42-induced AD mouse model, it was verified that GO-Dau regulated the Nrf2/Keap1 anti-oxidative pathway and had a better effect on AD compared with GO or Dau alone(2) GO@Dau could enter the brain after nasal administration in AD mice
Research Models Human SH-SY5Y cells andAβ1-42-induced AD mouse model
Main Source
Ref. Link