| Effects |
(1) We constructed a biologically inspired nanocarrier, which possesses both BBB permeability and high Aβ-binding affinity for the intervention of AD.
(2) The brain delivery efficiency and Aβ-targeting ability of the nanocarrier was confirmed both in vitro and in vivo.
(3) Following the incorporation of α-M, a polyphenolic agent, the Aβ-binding affinity of the nanoformulation was not reduced but even enhanced. , the effects of ANC-α-M on facilitating the microglia-mediated uptake and degradation of Aβ1–42, decreasing amyloid deposition, attenuating microgliosis, and rescuing memory impairment in an AD mouse model were demonstrated. |
