| Effects |
(1) The ThT emission in the presence of GaN NPs does not only change with time and that the amplitude overlaps with the initial baseline of the kinetic runs containing Aβ40(2) The addition of GaN NPs markedly delays the aggregation kinetics of Aβ40. In the presence of 60 μg mL−1 GaN NPs, the value of τ50 increases to 1227 minutes , ca.18% longer than that of Aβ40 alone,. Increasing the GaN concentration to 73 μg mL−1 results in a two-fold increase in τ50 relative to that of Aβ40 in the absence of GaN NPs, up to 2197 minutes.(3) the τlag of the Aβ40 aggregation kinetics is approximately 700 minutes, and the addition of 67 μg mL−1 GaN increases the τlag value to 1349 minutes. This result suggests that the presence of appropriate amounts of GaN can delay the rate of critical oligomeric nucleus formation of Aβ(4) In the absence of GaN NPs, Aβ40 aggregated to form fibrils of a few micrometers long and produced large conglomerates(5) GaN NPs can delay the formation of the crucial nucleus in Aβ aggregation and slow down the rate of Aβ40 amyloid fibril formation. In addition, GaN NPs can also decrease the growth rate constant of Aβ40 amyloid formation. |
