Detailed Information for N00178
IPAD-DB ID N00178
Name HA-MMSN-1F12
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity no toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ1-42
Effects Reduce brain Aβ burden and neuroinflammation, and improve cognitive deficits in APP/PS1 mice；degrade Aβ aggregates in the brain into soluble Aβ42 species that are excreted through intestinal metabolism
Research Models APP/PS1 mice；Transwell model
Main Source
Ref. Link