Detailed Information for N00179
IPAD-DB ID N00179
Name PLGA-functionalized quercetin nanoparticles
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity The PLGA@QT NPs have low cytotoxicity when tested on SH-SY5Y cells in vitro.
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Aβ1-42
Effects (1) PLGA@QT NPs can inhibit the neurotoxicity of Zn2+-Aβ42 system and enhance the viability of neuron cells. (2) Injection of PLGA@QT NPs into APP/PS1 mice ameliorate cognition and memory impairments.
Research Models SH-SY5Y cell
Main Source
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