| IPAD-DB ID |
N00183 |
| Name |
PEGylated phospholipid nanomicelles |
| Category |
Nano-inhibitors |
| EC50 |
|
| IC50 |
|
| Inhibition |
|
| Toxicity |
Cytotoxicity study
was carried out using human neuroblastoma SHSY-5Y cell
paradigm that possess highly developed neurites and exhibit
high sensitivity against Ab-42 [3]. A series of physiologically
relevant Ab-42 concentrations (0.2–4 mM) were tested. Lipid
untreated Ab-42 demonstrated elevated neurotoxicity above
1 mM concentration. However, when incubated with PEGylated
phospholipid nanomicelles, Ab-42 neurotoxicity was signifi-
cantly mitigated and percentage survival was increased by
almost 30% compared to lipid untreated control. |
| ROS(reactive oxygen species) |
|
| Metal Chelating |
|
| BBB(blood-brain barrier) |
|
| Target Protein |
Aβ1-42 |
| Effects |
PEGylated phospholipid nanomicelles mitigate b-sheet formation and aggregation of Ab-42 in vitro.PEGylated phospholipid nanomicelles attenuate
neurotoxicity of Ab-42 in vitro. |
| Research Models |
Human neuroblastoma SHSY-5Y cell paradigm |
| Main Source |
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| Ref. Link |
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