| IPAD-DB ID |
N00187 |
| Name |
RVG-9R and BACE1 siRNA encapsulated with solid lipid nanoparticles (SLNs) |
| Category |
Nano-inhibitors |
| EC50 |
|
| IC50 |
|
| Inhibition |
|
| Toxicity |
|
| ROS(reactive oxygen species) |
|
| Metal Chelating |
|
| BBB(blood-brain barrier) |
NO |
| Target Protein |
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) |
| Effects |
BACE1 siRNA was complexed with RVG-9R to protect the oligonucleotide and enhance the intracellular nerve pathway when released from SLNs. The complex was loaded in SLNs, and total encapsulation was obtained via chitosan coating, which modified the ZP and the mucoadhesiveness of the system as well as the permeation ability of the siRNA through the epithelial cell, enhancing the intracellular transport. |
| Research Models |
Caco-2 epithelial-like phenotypes cell |
| Main Source |
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| Ref. Link |
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