Detailed Information for N00201
IPAD-DB ID N00201
Name Ethylene glycol-coated cerium oxide nanoparticles (EGCNPs)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein HLECs
Effects (1) EGCNPs with concentrations up to 200 μg ml−1 did not have any significant effect on cell viability, when compared to control cells at the two tested time points (p value < 0.05) . However, the 24 h exposure to concentrations of 400 μg ml−1 or higher resulted in a statistically significant decrease in viability ranging from 27% (at 400 μg ml−1) to 40% (1000 μg ml−1) . (2) From 50 to 200 μg ml−1 were safe and had no harmful effect on the morphology, proliferation, and cell membrane integrity of the HLECs after 72 h exposure.
Research Models Human lens epithelial cells (HLECs)
Main Source
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