Detailed Information for N00202
IPAD-DB ID N00202
Name magnesium oxide nanoparticles (MgO NPs)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier) PASS
Target Protein Human tau protein
Effects (1) That MgO NPs could significantly promote tau fibrillization, concentration-dependently (2) MgO NPs was higher than that of tau samples aged alone against N2a neuron-like cells. (3) The interaction of MgO NPs with tau can lead to acceleration of tau aggregation and underlying neurotoxicity
Research Models Mouse neuroblastoma (N2a) cell
Main Source
Ref. Link