hematite (α-Fe2O3) nanorhombohedra (N-Rhomb) (α-Fe 2 O 3 N-Rhomb)
Category
Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein
microglia
Effects
(1) N9 immortalized microglia were exposed to increasing concentrations of the smaller sized bare α-Fe2O3 N-Rhomb, the light microscopy images show that N9 microglia did indeed internalize α-Fe2O3 N-Rhomb and consequentially, remained viable after treatment;(2) Cells treated with 100 μg mL–1 of RhB-labeled α-Fe2O3 N-Rhomb possessed significantly higher total cell fluorescence especially when compared with not only untreated cells but also cells treated with 1 μg mL–1 and 10 μg mL–1 of RhB-labeled α-Fe2O3 N-Rhomb;(3) Microglia engulf Rh-B-labeled α-Fe2O3 N-Rhomb in a clathrin-dependent manner(4) RhB-labeled α-Fe2O3 N-Rhomb are not toxic to microglia at therapeutic concentrations;(5) RhB-labeled α-Fe2O3 N-Rhomb do not cause in vitro microglial activation(6) RhB-labeled α-Fe2O3 N-Rhomb do not trigger either nitric oxide or ROS production in vitro
Research Models
Microglia, the immuno-competent cells associated with the CNS
