Detailed Information for N00217
IPAD-DB ID N00217
Name ferulic acid (FA)
Category Nano-inhibitors
EC50
IC50
Inhibition
Toxicity
ROS(reactive oxygen species)
Metal Chelating
BBB(blood-brain barrier)
Target Protein Peroxiredoxin,
Effects (1) A treatment, in particular if loaded into SLNs, decreased ROS generation, restored mitochondrial membrane potential (Deltapsi(m) ) and reduced cytochrome c release and intrinsic pathway apoptosis activation. (2) FA modulated the expression of Peroxiredoxin, an anti-oxidative protein, and attenuated phosphorylation of ERK1/2 activated by Abeta oligomers.
Research Models LAN5 human neuroblastoma cell line
Main Source
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