| IPAD-DB ID |
N00222 |
| Name |
Fe-MIL-88B-NH2-NOTA-DMK6240/MB |
| Category |
Nano-inhibitors |
| EC50 |
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| IC50 |
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| Inhibition |
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| Toxicity |
The cell ability is 71% when treated with 100 μg/mL of Fe-MIL-88B-NH2-NOTA-DMK6240/MB due to the cumulative release of MB. |
| ROS(reactive oxygen species) |
The Fe in the disease area could generate a high reactive oxygen species (ROS) level by the Fenton reaction.
oxygen species (ROS) level by the Fenton reaction. |
| Metal Chelating |
Fe |
| BBB(blood-brain barrier) |
PASS |
| Target Protein |
Tau protein |
| Effects |
(1) Fe-MIL88B-NH2-NOTA-DMK6240/ MB can effectively protect neurons against death.(2) The tau hyperphosphorylation inhibition effect of Fe-MIL88B-NH2 NOTA-DMK6240/MB contributes to improving memory loss in AD model rats. |
| Research Models |
SH-SY5Y cells, heparin, OA-induced cell, AD model rats |
| Main Source |
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| Ref. Link |
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